The Analysis of Clinical Symptom and Pathologic Change in Duodenogastric Reflux Patients and Observation the Theraputic Effect of Qingreliqi Granules

Abstract: Part One Observation of synchronously 24-hour bile reflux and alkali reflux monitoring in primary pathological patients and the relationship with the clinical symptom Objective To explore the characteristic of primary duodeno-gastric reflux(DGR), and the relationship among clinical symptom, bile reflux and alkali reflux through synchronously monitoring 24-hour intro-gastric pH and bilirubin absorbance. Methods 1 Subjects: 43 patients in primary pathological DGR group, 25 males, 18 females, age 19-50 years old. 10 subjects in control group, 8 males, 2 females, age were 36-60 years old. All patients were randomly recruited from patients seek health consult in the Digestive Department of Fourth Hospital Attached to Hebei Medical University for upper gastro-duodenal symptoms. And all patients fell into corresponding registered standards. 2 Methods 2.1 Questionnaire filling: Each DGR patient filled a questionnaire recorded clinical symptom, habits of smoking, drinking, eating irritant food, medicine taken history and formerly medical history. According to the degree of six symptoms, upper-abdominal pain, bloating, belching, vomiting bitter water, anorexia, nausea, symptom scores were graded. The total symptom scores of each symptom was symptom integral. 2.2 24-hours intro-gastric pH and bile reflux synchronously monitoring: 24-hours intro-gastric pH and bile reflux were synchronously monitored in 43 DGR patients and 10 control subjects. Bilirubin absorbance